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Tirzepatide (Zepbound/Mounjaro): A dual GLP-1/GIP receptor agonist undergoing evaluation for MASH after demonstrating significant liver fat reduction in studies.Retatrutide: A "triple agonist" targeting GLP-1, GIP, and glucagon (GCGR) receptors, which has shown "unprecedented" efficacy in weight loss and is being evaluated for metabolic diseases including MASH

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Initial studies suggest that such therapies can improve insulin secretion, assist pancreatic beta cell preservation and enhance insulin-mediated glucose metabolism while reducing glucagon secretion and risk of fatty liver disease

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