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Glucagon is emerging as a hormone with dual facets in metabolic diseases, characterized by its contrasting physiological responses of inducing hyperglycemia and promoting weight loss through increased energy metabolism [104]

Dextran sulfate sodium-induced murine colitis activates NF-kappa B and increases galanin-1 receptor expression

However, regular physical activity improves insulin sensitivity and metabolic health , which may enhance the body's responsiveness to GLP-1 over time

Abrupt Discontinuation Stopping GLP-1 abruptlyrather than tapering the dose over 48 weeksamplifies hunger rebound and increases the likelihood of rapid weight gain

Results also found that the stimulative and sedative effects of alcohol intoxication are reduced when taking these medications

Whether GLP- 1 increases energy expenditure has also been studied