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Outcomes and follow-up The primary outcome was the occurrence of a diagnosis code for hyperkalemia in the inpatient or outpatient setting (supplemental table 2 gives definitions)

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Zhou Y., Li Z., Cao X., Ma H., White P.F., Xu X., Jiang Y., Sun X., Cui Y

In cardiovascular applications, gadolinium-chelated GLP-1 lipid NPs permit MRI-guided delivery to diabetic myocardium, while ultrasound-targeted microbubble destruction (UTMD) combined with semaglutide has reversed ventricular remodeling in diabetic rats [453, 454]

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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]