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Consequently, as discussed in a comprehensive review [152], a large portion of intestinal GLP-1 is already degraded in the capillaries of the distal gut with an estimated 25% of active GLP-1 reaching the liver and only 1015% reaching the general circulation [152,176,183,191]

Dedicated RCTs or real-world studies that specifically enroll Black, Hispanic, Indigenous, or other underrepresented populations may help fill this gap

doi: 10.1007/s00125-007-0753-6

Pharmacies should be aware of a few practical realities: Cold-chain storage is required: all GLP-1 injectable pens must be stored at 2-8C

You get access to all available doses including higher strengths not available in Ireland

DPP-4 inhibitors also have a favorable cardiovascular safety profile [141]