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Exercise preserves muscle mass (which prevents metabolic slowdown), activates independent appetite-suppression pathways in your brain, and improves insulin sensitivity

Data on the renal benefits of GLP1RAs were initially reported from analyses of secondary outcomes in cardiovascular outcome trials, which also measured estimated glomerular filtration rate (eGFR) and albuminuria [44]

This dual mechanism is why tirzepatide produces greater weight loss in clinical trials and why the dosing numbers look completely different