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C., Amiel, S
If its urgent progressive condylar resorption, severe sleep apnea, an ankylosed joint, something actively getting worse the conversation is different and has to be individualized

Healthy Weight Loss Maintenance with Exercise, GLP-1 Receptor Agonist, or Both Combined Followed by a Year without Treatment: A Post-Treatment Analysis of a Randomised Placebo-Controlled Trial

The REWIND trial investigated the cardiovascular benefits of dulaglutide, a GLP-1 receptor agonist, in a population of 9,901 patients with T2DM aged 50+ and either established CVD or risk factors

Lee MMY, Sattar N, Pop-Busui R, Deanfield J, Emerson SS, Inzucchi SE, Mann JFE, Marx N, Mulvagh SL, Poulter NR, Badve SV, Pratley RE, Perkovic V, Buse JB, McGuire DK

Environmental factors such as bedroom temperature, bedding materials, and sleepwear should also be evaluated before pursuing extensive medical workup
