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Another study on alcohol use disorder (AUD) found that 168Ser allele (rs6923761) was associated with AUD in humans

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The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation

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doi: 10.1089/thy.2023.0284

Consistent with a role for NTS GLP-1R signaling in mediating the nausea outcomes induced by this system, GLP-1R blockade attenuates anorexia and weight loss when infused into the NTS of tumor-bearing rats [153], and reduces pica induced by icv infusion in cisplatin-treated rats treated [154]