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Due to their large molecular weight and hydrophilic nature, GLP1 agonists face challenges with oral delivery, including poor and variable gastrointestinal absorption, leading to low bioavailability

it is sometimes used off-label to treat prediabetes and leads to modest weight loss

Extracellular vesicles as a next-generation drug delivery platform

Track patterns

another related possibility is that proving bioequivalence for drug-device combinations to earn FDA approval may be challenging as compared to oral formulations and thus attracts fewer potential competitors
