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As fat mass decreases, leptin levels drop

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This suggests there is biological overlap between hormone changes and incretin signaling, though the precise interactions are still being studied

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Retatrutide: Designed to Last One of the newest GLP-1 medications in development is retatrutide , a triple agonist (GLP-1, GIP, and glucagon receptors) designed with an approximate 6-day half-life , thanks to advanced pharmaceutical engineering