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Eli Lilly, the maker of Zepbound, announced Tuesday it will begin selling the weight loss drug directly to consumers through the company's direct pharmacy, LillyDirect

This dual mechanism is what separates tirzepatide from single-receptor drugs like semaglutide, which only targets GLP-1

Common issues include nausea, vomiting, diarrhea, and constipation, which are typically mild to moderate and most frequent during dose escalation

The standard dose escalation begins at 2.5 mg subcutaneously once weekly for four weeks, followed by increases to 5 mg, 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg at four-week intervals as tolerated

GLP-1 controls specific types of appetite rather than baseline hunger

The medication enhances physiological satiety signals, but behavioral patterns and food choices remain important determinants of overall success