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Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis

Many patients ask whether L-carnitine supplements work alongside GLP-1 medications like tirzepatide

Its cognitive-support properties have been extensively studied

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an important therapeutic class for the management of type 2 diabetes mellitus (T2DM) and obesity owing to their ability to improve glycemic control, promote weight loss, reduce cardiometabolic parameters, and have the added advantage of a low risk of hypoglycemia due to glucose-independent insulin secretion

Therapeutic interventions should ideally correct both defects