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342344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis

A 10-year DCF model for a drug whose exclusivity actually terminates in seven years is not a 10-year DCF model

Instead, CMS is extending the duration of a separate short-term program, called the Medicare GLP-1 Bridge, which was originally scheduled to run from July-December 2026 but will now run through the end of 2027

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The efficacy of GLP-1R agonists is presumably because improving adipose tissue dysfunction minimizes an important source of adipocytokines which may promote dermal inflammation