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The covariates were adjusted in the PSM model for a priori-identified potential confounders, such as age, sex, race/ethnicity, nicotine dependence, BMI, type 2 diabetes, hypertension, hyperlipidaemia, hypercholesterolaemia, chronic respiratory disease, chronic renal diseases, BP, chronic kidney disease, peripheral vascular diseases, diabetes-related microvascular complications, glomerular diseases, cirrhosis of the liver, osteoporosis, sleep apnoea, abnormal laboratory findings (HbA 1c , serum cholesterol, LDL-cholesterol, HDL-cholesterol and triacylglycerol [TG]) and intake of cardiovascular medications (Table 1)

The Stein Institute for Research on Aging plans to translate these results into individualized aging dashboards to track biological aging with epigenetic clocks, enabling clinicians to design personalized therapies that target the underlying mechanisms of aging and help prevent agerelated diseases

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Rats were individually housed at 22 C on a reverse light:dark cycle (dark from 11:00 to 23:00 h), and provided with ad libitum access to 45% HFD (D12451, Research Diets, Inc., USA) and drinking water

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For women with obesity who do not achieve adequate metabolic or reproductive improvement with lifestyle interventions or pharmacologic therapy, bariatric surgery may be considered