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Semaglutide is a GLP-1 receptor agonist and one of the most extensively researched compounds in the weight loss and metabolic space

There is direct evidence comparing semaglutide to sitagliptin and dulaglutide in patients inadequately controlled on one oral antidiabetic drug (OAD), and to exenatide or insulin glargine in patients with inadequate glycemic control with one or two OADs, however data are lacking for other comparators

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