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Dual benefits for patients struggling with obesity and pain The TRIUMPH-4 trial enrolled 445 participants with obesity or overweight and knee osteoarthritis who did not have diabetes

MOTS-c Reconstitution Math MOTS-c - common doses at common vial sizes Vial Size 5 mg BAC Water 1.0 mL Concentration 5 mg/mL 5 mg Dose 1.0 mL (100 units) 2.5 mg Dose 0.50 mL (50 units) 1 mg Dose 0.20 mL (20 units) 200 mcg Dose 0.04 mL (4 units) Vial Size 5 mg BAC Water 2.0 mL Concentration 2.5 mg/mL 5 mg Dose 2.0 mL (200 units*) 2.5 mg Dose 1.0 mL (100 units) 1 mg Dose 0.40 mL (40 units) 200 mcg Dose 0.08 mL (8 units) Vial Size 10 mg BAC Water 1.0 mL Concentration 10 mg/mL 5 mg Dose 0.50 mL (50 units) 2.5 mg Dose 0.25 mL (25 units) 1 mg Dose 0.10 mL (10 units) 200 mcg Dose 0.02 mL (2 units) Vial Size 10 mg BAC Water 2.0 mL Concentration 5 mg/mL 5 mg Dose 1.0 mL (100 units) 2.5 mg Dose 0.50 mL (50 units) 1 mg Dose 0.20 mL (20 units) 200 mcg Dose 0.04 mL (4 units) Vial Size 10 mg BAC Water 3.0 mL Concentration 3.33 mg/mL 5 mg Dose 1.50 mL (150 units*) 2.5 mg Dose 0.75 mL (75 units) 1 mg Dose 0.30 mL (30 units) 200 mcg Dose 0.06 mL (6 units) * Volumes above 100 units exceed a standard 1 mL insulin syringe

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Tirzepatide resulted in a greater effect on TBWL% versus semaglutide in those patients

Oral GLP-1 therapies are viewed as a major future growth segment because they can improve access and reduce injection-related barriers

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