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GLP-1 RAs act by mimicking a hormone known as glucagon-like peptide 1, or GLP-1

Similarly, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, GLP-1 analogues were reported to protect the brain from MPTP-induced pathological effects, such as movement disorders, increased levels of -synuclein, chronic inflammation in the brain, loss of dopaminergic neurons, oxidative stress, and expression of growth factors (65)

Particular caution is needed when taking bisacodyl alongside diuretics, corticosteroids or digoxin, as the resulting hypokalaemia may increase the risk of digoxin toxicity

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Some patients notice weight changes soon after starting the medication, while others may see slower progress