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Recent studies using scintigraphy suggest that long-acting GLP-1 RAs may have fewer gastric effects than short-acting formulations due to the phenomenon of tachyphylaxis [20]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 420.Moon M.J., Lee Y.N., Park S., Reyes-Alcaraz A., Hwang J.I., Millar R.P

A falta de los resultados de los estudios de seguridad cardiovascular en obesidad (SURMOUNT MMO) y diabetes (SURPASS-CVOT), TZP ha mostrado en el ensayo SURMOUNT-1 una reduccin de la prediccin a 10 aos de riesgo en pacientes con obesidad y riesgo inicial intermedio-alto de enfermedad cardiovascular43

In animal experiments, the GLP-1RA liraglutide was found to stimulate the secretion of ANP by increasing the levels of Epac2, which is a downstream target of GLP-1R signaling in cardiomyocytes (132), However, this finding seemed to contradict the results of clinical studies in which no increase was observed in the levels of ANP in healthy people and patients with T2MD