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The preparation method according to claim 1, wherein in step 1), the main chain is sequentially synthesized from the C end to the N end on the solid-phase synthetic resin, then the side chain protecting group of Lys is removed, and the side chain is coupled to obtain the fully-protected coupling product of the semaglutide and the solid-phase synthetic resin

Dose escalation GRAPHICAL ABSTRACT INTRODUCTION Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the management of type 2 diabetes mellitus (T2DM) due to their dual effects on glycemic control and body weight

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doi: 10.1016/s0196-9781(97)00016-8 91 FrieboesRMMurckHMaierPSchierTHolsboerFSteigerA
Int J Mol Sci 26(11): 5338
