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Moreover, the regulation of sodium and calcium homeostasis in cardiomyocytes and coronary endothelium is directly translated into improved contractility and relaxation of the heart ( Diuretic and natriuretic effects of SGLT2 inhibitors contribute to the reduction of intravascular volume and decrease in blood pressure, lowering afterload, improving cardiac efficiency, and reducing ventricular mass index (Mazidi et al., 2017

J Endocrinol 219:5968 Mieczkowska A, Mansur S, Bouvard B, Flatt PR, Thorens B, Irwin N, Chappard D, Mabilleau G (2015) Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength