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The most striking protective effects of SGLT2is were a marked reduction in hospitalization for heart failure and a remarkable reduced progression of chronic kidney disease

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Here, the authors show that remote ischaemic preconditioning releases the gut hormone GLP-1, which relaxes cardiac pericytes via KATP channels to reduce capillary constriction and no-reflow.

A little over a week after announcing that the Evoke and Evoke+ studies failed to show that oral semaglutide could slow cognition decline in patients with Alzheimers disease, investors and researchers got the first look at the actual data from the studies, which were presented at the Clinical Trials on Alzheimers Disease 2025 meeting.