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Despite demonstrating robust glycemic efficacy, both agents were eventually discontinued due to distinct tolerability and safety concerns, diverging in severity and clinical implications

[DOI] [PubMed] [Google Scholar] 126.Barbieri M., Marfella R., Esposito A., Rizzo M.R., Angellotti E., Mauro C., Siniscalchi M., Chirico F., Caiazzo P., Furbatto F., et al

Acknowledgements We thank Milena Braga-Basaria, MD (Voxmed Medical Communications) for critically reviewing and suggesting improvements to the manuscript

Liver enzymes (ALT, AST): Elevated liver enzymes before starting GLP-1 therapy common in people with non-alcoholic fatty liver disease, which frequently accompanies the metabolic conditions these medications treat need to be documented

Body composition and sarcopenia concerns have generated moderate but rapidly growing publication volume

The downsides of microdosing GLP-1s The main downside is that you likely wont see results quite as quickly as you would with a higher dose