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PKA further activates the cAMP-response element binding protein (CREB) and the transducer of regulated CREB activity 2, leading to enhanced insulin receptor substrate 2 gene expression and promotion of -cell proliferation (26)

These data are in agreement with non-controlled clinical studies reporting that 72 h of native GLP-1 infusion improved regional and global left ventricular performance in patients with acute myocardial infarction and severe systolic dysfunction [619]

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