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Abstract Objective To synthesize the current preclinical and clinical evidence on the utility and potential mechanisms of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as a therapeutic strategy for major ophthalmic diseases, including diabetic retinopathy, glaucoma, and age-related macular degeneration

Alternative Comparison Healthcare providers can help evaluate appropriate alternatives based on: Medical history Treatment goals Coverage options Cost considerations Individual response Implementation Support Successful medication access requires a coordinated effort between multiple points

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Limitations of Use: Compounded semaglutide should not be used in combination with other semaglutide-containing products or any other GLP-1 receptor agonist The safety and efficacy of coadministration with other products for weight loss have not been established Compounded semaglutide has not been studied in patients with a history of pancreatitis Note: Compounded medications are not FDA approved and do not have indications for treatment as an FDA approved medication would

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Nzakizwanayo J, Dedi C, Standen G