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Regeneron is also collaborating with AstraZeneca on small-molecule, GPR75-targeting obesity drugs based on their own genetic research

Tirzepatide (Zepbound/Mounjaro): A dual GLP-1/GIP receptor agonist undergoing evaluation for MASH after demonstrating significant liver fat reduction in studies.Retatrutide: A "triple agonist" targeting GLP-1, GIP, and glucagon (GCGR) receptors, which has shown "unprecedented" efficacy in weight loss and is being evaluated for metabolic diseases including MASH

Individuals achieving 5% weight loss from baseline body weight had significantly lower AF incidence (OR 0.83, 95% CI 0.780.89), whereas no significant differences were observed in those with no weight loss or weight gain (OR 1.05, 95% CI 0.971.12)

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Weight management app Noom has revealed a major update to its GLP-1 Companion service to accompany and optimize popular GLP-1 drug therapies, which can cause temporary and long-term side effects like critical nutritional gaps and muscle loss