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While these earlier reports identified obesity as a major risk factor for both HF with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF), more recent studies suggested that obesity might be more strongly associated with the risk of developing HFpEF than HFrEF [3]

Meglitinides : Such as repaglinide or nateglinide, which also stimulate insulin release

GLP-1 drugs mimic it

This creates compounding effects that single or dual-agonist peptides cannot match

Similarly, a nationwide cohort study in Taiwan demonstrated that GLP-1RAs could be associated with a lower risk of cardiopulmonary outcomes and all-cause mortality than non-GLP-1RAs in patients with T2D and COPD (Yen et al., 2024)

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