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Pancreatic DPP-4 As well as influencing glucose homeostasis through its more widespread systemic effects, as discussed above, there is some evidence to suggest that DPP-4 may have local actions in the endocrine pancreas

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Findings are not yet published but available from the US FDA including placebo-corrected and dose-dependent declines in bone mineral density of 0.9%1.2% at total hip, 0.3%0.7% at lumbar spine, and 0.1% at femoral neck with the use of canagliflozin

Journal of Indian Association of Pediatric Surgeons