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health benefits of glp-1 agonists The cardiovascular effects receptor beyond obesity and type 2 diabetes: An anti-atherosclerotic action GLP-1 Receptor Agonists and Research
Description
21 Antiarrhythmic Properties GLP-1RAs may lower the risk of AF, a common comorbidity in HF that worsens prognosis, by reducing the volume of epicardial fat, modulating calcium handling within cardiomyocytes and improving left atrial remodelling

doi: 10.1210/clinem/dgaa285

For candidates on GLP-1s, a few specific factors come into focus

p38beta Mitogen- activated protein kinase signaling mediates exenatide-stimulated microglial beta-endorphin expression
However, orforglipron patients lost around twice as much, at between 4.7% and 7.9% of their weight

Back WHO (1 March 2024) 'Obesity and overweight', WHO News
