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While effective dosing ranges for GLP-1 medicines such as semaglutide and tirzepatide are well established for treatment of T2D and obesity, the dose-response relationships for reduction of inflammation or for conditions such as substance abuse or neurodegenerative disorders like Alzheimers remain unclear

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Clinical data shows that patients who stop mid-treatment often regain 50% or more of lost weight within 12 months, particularly if diet and exercise habits haven't been firmly established