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Injection site does not influence systemic side effects like dry mouth

Jane Holmes-Walker, James J.H

- - - A new 2-year comparative study from NYU Langone just droppedand the results are clear: Bariatric Surgery vs GLP-1s (semaglutide/tirzepatide): 25.7% total body weight loss with surgery vs 5.3% with GLP-1s (intention-to-treat) Even in per-protocol analysis (continuous GLP-1 use), surgery still outperformed: 24.6% vs 7.6% Surgery had better HbA1c improvement, too Translational Insight: Yes, the relatively low weight loss in the medication group was partly due to therapy interruptions and discontinuation

Creatine monohydrate at 5 grams daily has no known interactions with GLP-1 medications

Medical costs are 2.3 times higher in patients with diabetes, with health care expenditures exceeding $174 billion annually

The analysis focused on 22 neurological and psychiatric outcomes, including cognitive deficits, dementia, parkinsonism, psychosis, and substance misuse