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This reflects a broader industry reality: large pharma companies may prefer acquiring differentiated platforms rather than building from zero in an increasingly crowded race

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It has also been suggested that hepatic hypoinsulinemia may reduce insulin-like growth factor 1 (IGF-1) levels, which may contribute to IR as well by increasing growth hormone and IGF binding globulins (29)

This happens because the drug's appetite-suppressing effects wear off

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