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Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases

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The major parts of the ligand binding domain of DPP4 are defined by subdomains called S1, S2, and S3

60 In a phase 2 trial of individuals with alcohol use disorder, semaglutide reduced alcohol consumption during a laboratory self-administration task (standardized regression coefficient []: 0.48, 95% CI 0.85, 0.11) and lowered both drinks per drinking day (: 0.41, 95% CI 0.73, 0.09) and weekly alcohol craving scores (: 0.39, 95% CI 0.73, 0.06) compared to placebo