glp-1 pregnancy category What to know about the new era of drugs Indications for GLP-1/GIP RA Summary

In the United States, almost three-quarters of adults are considered overweight and 43% are obese, nearly tripling the prevalence of obesity observed 40 years ago 1

Oral semaglutide (brand name Rybelsus) uses a specific absorption enhancer to survive the digestive tract and reach the bloodstream, but its oral bioavailability is very low compared with injectables

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region

doi: 10.1056/NEJMoa0805017

Obesity leeches the economy

Meeting these demands goes beyond incremental upgrades to existing infrastructure and instead calls for purpose-built capabilities and closer coordination between pharmaceutical companies and CDMOs