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The results showed that after 12 months of treatment, the total fat mass of the patients decreased by 18%, the decline in lean body mass stabilized after the initial appearance of treatment, and grip strength improved significantly

Whilst some blood glucose improvements may appear within the first week, the medication reaches steady-state concentrations after 4 to 5 weeks, with maximal glycaemic effects typically observed over 3 to 6 months following dose titration

A Quantitative Systematic Review of Normal Values for Short-Term Heart Rate Variability in Healthy Adults

doi: 10.1016/0031-9422(95)00782-2

They have obesity, but it's preclinical obesity as a disease

Clinical trials followed a step-up dosing schedule, starting low and moving up gradually