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This variability underlies the importance of personalized prescribinga core principle at PlexusDx, where genetic and metabolic factors guide therapy selection

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1 Schematic representation of the distribution of glucagon-like peptide-1 (GLP-1) receptors (GLP-1Rs) and the cardiovascular and systemic effects of GLP-1

And to further explore whether the activation of GLP-1R exerted a protective effect on chondrocytes, the GLP-1R agonist liraglutide was used in IL-1-stimulated chondrocytes

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Importantly, treatment with retatrutide not only resulted in robust weight reduction, but also in clear improvements in assessed cardiometabolic health measures