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"Obesity is a chronic disease, just like diabetes, high blood pressure and high cholesterol," Aronne said

While 2.5 mg may produce initial appetite suppression and modest weight loss, clinical data shows this dose provides suboptimal long term efficacy

Skin elasticity and collagen production decrease with age and significant weight loss, making the skin more prone to sagging

The mechanism might involve direct antiemetic effects of B12, or it might reflect improved overall metabolic function when vitamin status is maintained

For pens, look for features specified by the manufacturer, such as a purple injector button that does not extend and no dial-up for a dose

Semaglutide also slows stomach emptying, which may help control appetite but can contribute to digestive side effects