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These include a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, severe pancreatitis, diabetic retinopathy complications, or active gallbladder disease

Means lower Emerging observational studies and small interventional trials suggest that GLP-1 RAs may be used in patients with advanced CKD with preserved glucose-lowering efficacy and a relatively low intrinsic risk of hypoglycemia compared with insulin and sulfonylureas ( Semaglutide has recently received expanded regulatory approval for use in patients with T2DM and CKD, reflecting growing confidence in its renal safety profile and potential kidney-protective benefits ( In Saudi Arabia, T2DM prevalence is among the highest worldwide and is accompanied by high rates of obesity, cardiovascular disease, and CKD ( Therefore, this multicenter retrospective study aimed to evaluate the real-world safety and effectiveness of semaglutide in patients with ESRD receiving care at Saudi tertiary healthcare centers, with a focus on glycemic outcomes, body weight changes, cardiovascular events, renal safety, and treatment tolerability

Pharmaceutics , 17 (8), 1036

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ABOUT THE AUTHORZarafshan Shiraz A lifestyle aficionado with a knack for crafting engaging news across fashion, health, relationships, art and culture, travel, recipes, festivals and pets

However, researchers suspect other biological mechanisms could also be involved