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include sitagliptin (Januvia), which was approved in 2006, followed by saxagliptin (Onglyza) in 2009, linagliptin (Tradjenta) in 2011, and alogliptin (Nesina) in 2013

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This elevation prompts IR, which aligns with oxidative stress and mitochondrial dysfunction, both central to the pathophysiology of T2DM

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