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24 This can be due to differences in the specific drug used, the dosage, the duration of the study, the characteristics of the participants (age, baseline health) 9 , the methods used to measure body composition (DXA, BIA, MRI all have different strengths and weaknesses) 16 , and whether interventions like dietary counseling (especially protein emphasis) and exercise were included

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Clinical trials leading to the FDA approval of oral semaglutide for weight loss, such as the OASIS studies, have demonstrated significant efficacy comparable to injectable GLP-1 therapies

Regular human insulin was used before meals, as needed

15 In our subgroup analysis, continuation of GLP-1 and/or GIP agonists in conjunction with a clear liquid diet did not appear to increase residual gastric volume, suggesting that medication discontinuation may not be necessary when this dietary strategy is employed