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For each medication, we defined a start date (date of first redemption) and an end date (date of last redemption plus the number of daily doses redeemed on that date)

Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

In conclusion, GLP-1R activation triggers a series of complex physiological responses in pancreatic -cells that work together to increase insulin secretion, inhibit -cell apoptosis and stimulate proliferation, protect -cells and ultimately regulate blood glucose

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This can be associated with the development of neurodegenerative disorders [136]

Conclusion In addition to the well-established role of GLP-1 to improve glucose homeostasis, GLP-1R agonism has beneficial effects on body weight reduction