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Description
When the nutrients subsequently reach the distal gut, direct contact with the L-cells then triggers additional GLP-1 secretion into the circulation (as also reviewed in [320])

Back Philipson, LH, Bell, G, Polonsky, KS (27 Jan 2015) 'Donald F

The FDA has approved several agents specifically for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

Valencia-Rincn et al
Furthermore, this patient subgroup reported increased adverse events related to weight loss (ROR = 10.85, 95% CI 9.1212.91) and metabolic disturbances

Semaglutide modulates the reward system in the opposite direction
