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Although many preclinical studies suggest that GLP-1R agonism can act directly on neurons to prevent cell death, this neuroprotective property may be secondary to reduced glucotoxicity and inflammation in the brain that can result from weight loss and improvements in glycemic control (Berkseth et al., 2014)

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Acknowledgments Sushma Soni, CMPP, of inScience Communications, Springer Healthcare (Philadelphia, Pa.), and Amy Zannikos, PharmD, CMPP, on behalf of inScience Communications, Springer Healthcare, provided medical writing support, which was funded by AstraZeneca