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2326 Glitazones for type 2 diabetes therapy have been linked to serious side effects such as fluid retention, congestive heart failure, weight gain, bone loss, and increased risk of bladder cancer

This occurs through the activation of potassium channels, which results in membrane hyperpolarization of pancreatic -cells

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Semaglutide: A Review of its Pharmacological Properties and Clinical Efficacy in Type 2 Diabetes

One study found that rats who were administered semaglutide saw a significant decrease in cocaine-seeking behavior

For these reasons, GLP-1 analogues have been FDA-approved for treatment of obesity and diabetes, Dr