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Retatrutide ist der erste Triple-Agonist, der gleichzeitig an drei Inkretin-verwandte Rezeptoren bindet: den GIP-Rezeptor (GIPR), den GLP-1-Rezeptor (GLP-1R) und den Glukagon-Rezeptor (GCGR)

doi: 10.1007/s11095-013-0986-7

Valvular Heart Disease Associated with Fenfluramine-Phentermine

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These effects often subside as the body adjusts to the medication

In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]