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In all, 335 participants were randomized to switch to a placebo, and the researchers monitored changes in their weight and cardiovascular health metrics after the switch

Importantly, GLP-1 only triggers insulin when blood sugar is high, which reduces the risk of hypoglycemia (dangerously low blood sugar)

Research indicates consistent body weight reduction, with side effects that are generally manageable

One of the side effects that have been reported is quite similar to other injectable incretin-based therapies

JAMA 326 , 20732074 (2021)
Analysis of GLP-1 side effects reported to the US FDA suggest an increased reporting of various eye disorders across both patients with diabetes and those without
