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Discussion In this study we show that (i) acute and chronic administration of the GLP-1 receptor agonist Ex-4 results in a significant elevation in heart rate, (ii) centrally administered Ex-4 depresses spectral measures of HRV both acutely and chronically, and (iii) Ex-4 inhibits neurotransmission to cardiac vagal neurons in the nucleus ambiguus
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Combining immunomodulatory peptides with drugs like ocrelizumab or natalizumab that also affect the immune system creates the potential for unpredictable interactions
Yang Z, Lv Y, Yu M, Mei M, Xiang L, Zhao S, et al
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