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The mutational constraint spectrum quantified from variation in 141,456 humans

It only means that the FDA wants more definitive long-term data

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Research in people with type 2 diabetes has found that GLP-1 users have a higher chance of gallbladder and bile duct problems compared with those on other diabetes medications

Once the drugs are approved for use, they must be monitored carefully for any new adverse events and to ensure they continue to be effective at controlling diabetes over time [42]

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