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Comfort thresholds vary from patient to patient, and practitioners will discuss options for making the experience as pleasant as possible

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doi: 10.1016/j.medcli.2023.11.007

46 Adverse Effects and Tolerability of GLP-1RAs in Clinical Practice Although the cardiovascular benefits of GLP-1RAs are significant, their use is commonly associated with well-characterised adverse effects that can affect tolerability and long-term medication adherence, as detailed below

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They have also changed their website and systems a few times, leading to intermittent issues for those ordering during the transition periods