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Neurim Pharmaceuticals (2018)
This is particularly important for individuals with diabetes, as they may have reduced sensation in their lower extremities due to peripheral neuropathy

Figure 2 illustrates the ranges of blood KB concentrations observed across physiological, pathophysiological, and pathological states of ketogenesis, with concentrations primarily reflecting -HB levels

It has been reported that there is no reduction in its secretion in patients with T2DM [13] but a nearly total loss of insulinotropic effect is observed, even at supraphysiological concentrations, implying the existence of GIP resistance [14]

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