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Since being overweight or obese greatly increases the likelihood of developing colorectal cancer (CRC) [148]

Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T

53 Although dementia was not a primary outcome, a pooled analysis of 15,820 patients with type 2 diabetes randomised to GLP-1 receptor agonist treatment or placebo found a 50% reduction in dementia progression over a median of 3.6 years (15 cases in the placebo group vs 32 in the GLP-1 receptor agonist group)

These conditions are treatable and are not caused by semaglutide but may be unmasked or temporarily worsened by rapid weight loss and metabolic stress

Swallowing the compounded preparation would likely result in very limited absorption

Additionally, researchers noted that baseline eGFR differed between the two groups
