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Because these pathways are independent, GLP-1 does not interfere with thyroid hormone replacement therapy or thyroid function tests

[4] [5] The principal hypothesised risk is indirect: the marked reduction in food intake associated with retatrutide use may significantly lower dietary B12 consumption over time, particularly from animal-derived foods

Using data from ten randomized control trials with a total of 14,550 participants, the review's authors reported that the thyroid cancer incidence was less than 1%, which is not higher than the general population (although this cannot rule out small increases in cancer risk)